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J Am Acad Orthop Surg, Vol 12, No 1, January/February 2004, 55-64.
© 2004 the American Academy of Orthopaedic Surgeons
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Advances in Radionuclide Therapeutics in Orthopaedics

Herrick J. Siegel, MD, James V. Luck, Jr, MD and Michael E. Siegel, MD

Dr. H. Siegel is Assistant Professor, Division of Orthopaedic Surgery, Section of Orthopaedic Oncology, University of Alabama at Birmingham, Birmingham, AL. Dr. Luck is Professor, Department of Orthopaedic Surgery, UCLA/Orthopaedic Hospital of Los Angeles, Los Angeles, CA. Dr. M. Siegel is Professor of Radiology, Department of Nuclear Medicine, Orthopaedic Hospital of Los Angeles and Division of Nuclear Medicine, Los Angeles County + University of Southern California Medical Center, Los Angeles.

Reprint requests: Dr. H. Siegel, University of Alabama, Medical Faculty Office Towers #920, 510 20th Street South, Birmingham, AL 35294.

Radiopharmaceuticals not only are used for diagnostic purposes but also increasingly in the treatment of many orthopaedic-related disorders. With the development of specific bone-seeking radiopharmaceuticals, the side effects of treatment are minimized, therapeutic effects are sustained, and concomitant use with other modalities may have synergistic effects. These new radiopharmaceuticals, such as strontium 89 and samarium 153-ethylene diamine tetramethylene phosphate, have been used as palliative treatment for patients with bone pain from osseous metastases. Excellent clinical responses with acceptable hematologic toxicity have been observed, and clinical results rival those of external beam radiation therapy. Radiosynovectomy has become a procedure of choice at many institutions to treat recurrent hemarthrosis and chronic synovitis in patients whose hemophilia is poorly controlled with medical management. Radiosynovectomy also remains a viable option to treat chronic synovitis secondary to inflammatory arthropathies, particularly rheumatoid arthritis.




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P. Schneider, J. Farahati, and C. Reiners
Radiosynovectomy in Rheumatology, Orthopedics, and Hemophilia
J. Nucl. Med., January 1, 2005; 46(1_suppl): 48S - 54S.
[Abstract] [Full Text] [PDF]


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