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J Am Acad Orthop Surg, Vol 12, No 5, September/October 2004, 298-304.
© 2004 the American Academy of Orthopaedic Surgeons

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New Therapies in Tendon Reconstruction

Michael J. DeFranco, MD, Kathleen Derwin, PhD and Joseph P. Iannotti, MD, PhD

Dr. DeFranco is Resident, Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, OH. Dr. Derwin is Project Staff Scientist, Department of Biomedical Engineering, The Cleveland Clinic Foundation. Dr. Iannotti is Chairman, Department of Orthopaedic Surgery, The Cleveland Clinic Foundation.

Reprint requests: Dr. Iannotti, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.

Despite the use of various types of grafts, no surgical treatment currently exists to restore a tendon to its normal condition. Tissue engineering techniques are being used to develop therapies for tendon reconstruction. Biologic and synthetic scaffolds can both repair tendon defects and improve healing by allowing for the regeneration of the tendon’s natural biologic composition to restore its mechanical capacity. This process can be further enhanced through augmentation methods such as cell seeding, growth factor implantation, and gene therapy.







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Copyright © 2004 by the American Academy of Orthopaedic Surgeons.