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J Am Acad Orthop Surg, Vol 13, No 7, November 2005, 475-486.
© 2005 the American Academy of Orthopaedic Surgeons
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Secondary Osteoporosis

Kimberly Templeton, MD

Dr. Templeton is Associate Professor, Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, KS.

Neither Dr. Templeton nor the department with which she is affiliated has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article.

Reprint requests: Dr. Templeton, Department of Orthopaedic Surgery, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160.

Secondary osteoporosis occurs as a consequence of various lifestyle factors (eg, eating disorders, smoking, alcoholism), disease processes (eg, endocrinopathies, gastrointestinal tract disease, hepatobiliary disease), and treatment regimens that comprise corticosteroids or chemotherapeutic agents. Some of the disease entities underlying secondary osteoporosis may be clinically silent and identified only during evaluation for documented osteoporosis. The pathogenesis of osteoporosis in these settings is typically multifactorial. The loss of bone may be direct or indirect but ultimately is related to altered osteoblast or osteoclast function. Causes of secondary osteoporosis should especially be investigated in men at all ages and in premenopausal women with atraumatic fractures. In addition, patients with known risk factors should be evaluated. Early recognition and intervention are essential to prevent further loss of bone mass and to prevent fragility fractures.




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J. G. Skedros, C. L. Sybrowsky, and G. J. Stoddard
The Osteoporosis Self-Assessment Screening Tool: A Useful Tool for the Orthopaedic Surgeon
J. Bone Joint Surg. Am., April 1, 2007; 89(4): 765 - 772.
[Abstract] [Full Text] [PDF]


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