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Tissue Engineering Solutions for Traumatic Bone Loss

Dr. Goldstein is Henry Ruppenthal Family Professor of Orthopaedic Surgery and Bioengineering, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI.

Dr. Goldstein or the department with which he is affiliated has received research or institutional support from the National Institutes of Health. Dr. Goldstein or the department with which he is affiliated has stock or stock options held in Selective Genetics, Inc.

Tissue engineering strategies for the repair, replacement, or augmentation of bone defects involves the use of cells, matrices, and bioregulatory factors. The source (endogenous, exogenous) and character of these factors, however, may vary greatly among the many approaches taken by current investigators. Although the results of current tissue engineering methods for regenerating bone have shown great promise, the extent of damage to extremities associated with war injuries may require the development of techniques that differ substantially from current practice.