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Horizons in Prosthesis Development for the Restoration of Limb Function

Dr. Aaron is Professor, Department of Orthopaedics, Brown University, Providence, RI. Dr. Herr is Associate Professor, Media Arts and Sciences and Health Sciences and Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA. Dr. Ciombor is Associate Professor, Department of Orthopaedics, Brown University. Dr. Hochberg is Investigator in Neuroscience, Department of Neuroscience, Brown University. Dr. Donoghue is Professor, Department of Neuroscience, Brown University. Dr. Briant is Professor of Engineering, Division of Engineering, Brown University. Dr. Morgan is Associate Professor of Medical Science and Engineering, Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University. Dr. Ehrlich is Professor, Department of Orthopaedics, Brown University. All authors are also investigators at the Center for Restorative and Regenerative Medicine at the Providence VA Medical Center and Brown University, Providence, RI.

All of the authors or the departments with which they are affiliated have received research or institutional support from the Veterans Administration. Dr. Hochberg has received research or institutional support from Cyberkinetics Neurotechnology Systems, Inc. Dr. Donoghue has received research or institutional support from Cyberkinetics Neurotechnology Systems, Inc. Dr. Donoghue has stock or stock options held in Cyberkinetics Neurotechnology Systems, Inc. Dr. Donoghue serves as a consultant to or is an employee of Cyberkinetics Neurotechnology Systems, Inc. Dr. Ehrlich has received research or institutional support from Biomimetics, Inc. Dr. Ehrlich has stock or stock options held in Biomimetics, Inc. Dr. Ehrlich serves on the Biomimetics Advisory Board.

The focus of our research program is the restoration of limb function through a biohybrid approach. We consider the limb conceptually as a biohybrid organ consisting of biological tissue, endoprostheses (including neural devices and joint replacements), and exoprostheses. The biohybrid limb maximizes biological function and functional articulations with optimized human-prosthesis interfaces. Our long-term goals are to create biomimetic prostheses, optimized control systems for prostheses, and optimized human-prosthesis interfaces using both limb lengthening and osseointegration techniques.