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J Am Acad Orthop Surg, Vol 14, No 11, October 2006, 577-586.
© 2006 the American Academy of Orthopaedic Surgeons
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Surgical Manifestations of Paget’s Disease

Gregg R. Klein, MD and Javad Parvizi, MD, FRCS

Dr. Klein is Attending Physician, Department of Orthopaedic Surgery, Hackensack University Medical Center, Hackensack, NJ. Dr. Parvizi is Associate Professor, Rothman Institute of Orthopedics at Thomas Jefferson Hospital, Philadelphia, PA.

None of the following authors or the departments with which they are affiliated has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Klein and Dr. Parvizi.

Reprint requests: Dr. Parvizi, Rothman Institute of Orthopedics at Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107.

Paget’s disease is a chronic, nonmetabolic bone disorder characterized by increased bone resorption, bone formation, and remodeling. This unbalanced process may lead to osseous deformities, structural weakness, and altered joint biomechanics, all of which can make surgical reconstruction difficult. Although few patients with Paget’s disease require surgical treatment, successful surgical management of severe orthopaedic complications has improved the quality of life for these patients. Surgical options include osteotomy to correct long-bone deformity and arthroplasty to restore altered joint mechanics. Patients are at increased risk for surgical complications, such as blood loss and heterotopic bone formation. Issues relating to the surgical management of patients with Paget’s disease include appropriate preoperative diagnosis, technical challenges of surgery, and strategies to improve the long-term outcome of surgical intervention.






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Copyright © 2006 by the American Academy of Orthopaedic Surgeons.