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J Am Acad Orthop Surg, Vol 14, No 6, June 2006, 325-332.
© 2006 the American Academy of Orthopaedic Surgeons
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Proteomics: Applications to the Study of Rheumatoid Arthritis and Osteoarthritis

Reuben Gobezie, MD, Peter J. Millett, MD, MSc, David S. Sarracino, PhD, Christopher Evans, PhD and Thomas S. Thornhill, MD

Dr. Gobezie is Director, Musculoskeletal Proteomics, The Case Center for Proteomics, Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH. Dr. Millett is Director of Shoulder Surgery, Steadman Hawkins Clinic, Vail, CO. Dr. Sarracino is Director of Proteomics, Harvard Partners Center for Genomics and Genetics, Cambridge, MA. Dr. Evans is Professor, Orthopaedic Surgery, and Director, Center for Molecular Orthopaedics, Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Boston, MA. Dr. Thornhill is Professor, Orthopaedic Surgery, Harvard Medical School, and Chairman, Department of Orthopaedic Surgery, Brigham and Women’s Hospital.

None of the following authors or the departments with which they are affiliated has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Gobezie, Dr. Millett, Dr. Sarracino, Dr. Evans, and Dr. Thornhill.

Reprint requests: Dr. Gobezie, Case Center for Proteomics, Department of Orthopaedic Surgery, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106.

The study of both DNA and protein technologies has been marked by unprecedented achievement over the last decade. The completion of the Human Genome Project in 2001 is representative of a new era in genomics; likewise, proteomics research, which has revolutionized the way we study disease, offers the potential to unlock many of the pathophysiologic mechanisms underlying the clinical problems encountered by orthopaedic surgeons. These new fields are extending our approach to and investigation of the etiology and progression of musculoskeletal disorders, notably rheumatoid arthritis and osteoarthritis. Advances in proteomics technology may lead to the development of biomarkers for both rheumatoid arthritis and osteoarthritis. Such biomarkers would improve early detection of these diseases, measure response to treatment, and expand knowledge of disease pathogenesis.






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Copyright © 2006 by the American Academy of Orthopaedic Surgeons.