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The Use of Long-term Bioresorbable Scaffolds for Anterior Cruciate Ligament Repair

Dr. Altman is President and Chief Executive Officer, Serica Technologies, Inc, Medford, MA. Dr. Horan is Senior Director of Research and Development, Serica Technologies, Inc. Dr. Weitzel is Orthopaedic Surgeon, Boston Sports and Shoulder Center, Chestnut Hill, MA. Dr. Richmond is Chairman of Orthopaedic Surgery, New England Baptist Hospital, Boston, MA.

Dr. Altman or a member of his immediate family has received research or institutional support, has stock or stock options held in, and serves as a consultant to or is an employee of Serica Technologies, Inc. Dr. Horan or a member of her immediate family has stock or stock options held in and serves as a consultant to or is an employee of Serica Technologies, Inc. Dr. Weitzel or a member of his immediate family has stock or stock options held in and serves as a consultant to or is an employee of Serica Technologies, Inc. Dr. Richmond or a member of his immediate family has stock or stock options held in and serves as a consultant to or is an employee of Serica Technologies, Inc.

Reprint requests: Dr. Richmond, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120.

Perspectives on Modern Orthopaedics articles provide an objective appraisal of new or controversial techniques or areas of investigation in orthopaedic surgery.

The absence of adequate options to restore full knee joint function through anterior cruciate ligament reconstruction prompts the need to develop new ligament replacement strategies. Recent focus within the ligament engineering field has been on the establishment of appropriate anterior cruciate ligament graft design requirements and evaluation methods. A range of biomaterials and graft constructions has been explored in an attempt to identify the optimal ligament replacement. Thorough and standardized evaluation methods are required throughout all phases of development, from initial in vitro bench screening through a large animal in vivo model. The initial positive clinical, gross pathologic, histologic, and mechanical results from a 12-month in vivo goat study demonstrate the potential of bioengineered ligament devices.  

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