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J Am Acad Orthop Surg, Vol 16, No 4, April 2008, 188-198.
© 2008 the American Academy of Orthopaedic Surgeons
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Musculoskeletal Desmoid Tumors

Harish S. Hosalkar, MD, MBMS(Orth), FCPS(Orth), DNB(Orth), Jesse T. Torbert, MD, MS, Edward J. Fox, MD, Thomas F. Delaney, MD, Albert J. Aboulafia, MD and Richard D. Lackman, MD

Dr. Hosalkar is Clinical Instructor and Administrative Chief Resident, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA. Dr. Torbert is Orthopaedic Resident, Department of Orthopaedic Surgery, University of Pennsylvania. Dr. Fox is Attending Orthopaedic Surgeon, Department of Orthopaedic Surgery, University of Pennsylvania. Dr. Delaney is Medical Director and Associate Professor, Proton Therapy Center, Massachusetts General Hospital, Boston, MA. Dr. Aboulafia is Attending Orthopaedic Surgeon, Department of Orthopaedic Surgery, Cancer Institute, Sinai Hospital, Baltimore, MD. Dr. Lackman is Professor and Chairman, Department of Orthopaedic Surgery, University of Pennsylvania.

Dr. Lackman or a member of his immediate family has received research or institutional support from Stryker. None of the following authors or a member of their immediate families has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Hosalkar, Dr. Torbert, Dr. Fox, Dr. Delaney, and Dr. Aboulafia.

Reprint requests: Dr. Lackman, Department of Orthopaedic Surgery, University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104-4283.

Desmoid tumors are benign tumors that exhibit varying degrees of local aggressiveness and diverse growth patterns. Magnetic resonance imaging remains the modality of choice for assessment of the nature and size of the soft-tissue lesion and involvement of surrounding structures. Treatment strategies include surgery, chemotherapy, hormonal therapy, and radiation therapy, either individually or in combination. Despite the benign nature of these tumors, multidisciplinary care is needed to provide combined treatment options. Chemotherapy in low doses is an excellent first-round treatment in any patient in whom contemplated local treatment may produce local morbidity and adjacent tissue injury.  






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Copyright © 2008 by the American Academy of Orthopaedic Surgeons.