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J Am Acad Orthop Surg, Vol 16, No 4, April 2008, 228-236.
© 2008 the American Academy of Orthopaedic Surgeons

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Congenital Pseudarthrosis of the Tibia

Kelly L. Vander Have, MD, Robert N. Hensinger, MD, Michelle Caird, MD, Charles Johnston, MD and Frances A. Farley, MD

Dr. Vander Have is Assistant Professor, Department of Orthopaedic Surgery, University of Michigan Health System, University of Michigan, Ann Arbor, MI. Dr. Hensinger is Professor, Department of Orthopaedic Surgery, University of Michigan Health System, University of Michigan, Ann Arbor. Dr. Caird is Assistant Professor, Department of Orthopaedic Surgery, University of Michigan Health System, University of Michigan, Ann Arbor. Dr. Johnston is Professor, Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, and Assistant Chief of Staff and Medical Director of Research, Texas Scottish Rite Hospital for Children, Dallas, TX. Dr. Farley is Associate Professor, Department of Orthopaedic Surgery, University of Michigan Health System, University of Michigan, Ann Arbor.

Dr. Farley or a member of her immediate family has stock or stock options held in Medtronic. None of the following authors or a member of their immediate families has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Vander Have, Dr. Hensinger, Dr. Caird, and Dr. Johnston.

Reprint requests: Dr. Vander Have, University of Michigan, Taubmann Center 2912, E 1500 Medical Ct Drive, Ann Arbor, MI 48109.

Congenital pseudarthrosis of the tibia is characterized by anterolateral deformity of the tibia and shortening of the limb. Its etiology remains unclear. Although several classification systems have been proposed, none provides specific guidelines for management. Treatment remains challenging. The goal is to obtain and maintain union while minimizing deformity. The basic biologic considerations with surgical intervention include resection of the pseudarthrosis and bridging of the defect with stable fixation. Intramedullary stabilization, free vascularized fibula, and Ilizarov external fixation are among the most frequently used methods of treatment. In addition, bone morphogenetic protein recently has shown promise. Nevertheless, despite improvements in healing rates with congenital pseudarthrosis of the tibia, the potential for amputation in failed cases persists. 







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Copyright © 2008 by the American Academy of Orthopaedic Surgeons.