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J Am Acad Orthop Surg, Vol 16, No 5, May 2008, 283-293.
© 2008 the American Academy of Orthopaedic Surgeons
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Prophylactic Antibiotics in Orthopaedic Surgery

Laura Prokuski, MD

Dr. Prokuski is Associate Professor, University of Wisconsin Hospitals, Madison, WI.

Neither Dr. Prokuski nor a member of her immediate family has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article.

Reprint requests: Dr. Prokuski, University of Wisconsin Hospitals, 600 Highland Avenue, Madison, WI 53792.

The use of prophylactic antibiotics in orthopaedic surgery is effective in reducing surgical site infections in hip and knee arthroplasty, spine surgery, and open reduction and internal fixation of fractures. To maximize the beneficial effect of prophylactic antibiotics while minimizing adverse effects, the correct antimicrobial agent must be selected, the drug must be administered just before incision, and the duration of administration should not exceed 24 hours. 




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