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J Am Acad Orthop Surg, Vol 16, No suppl_1, July 2008, S42-S48.
© 2008 the American Academy of Orthopaedic Surgeons
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What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?

Rocky S. Tuan, PhD, Francis Young-In Lee, MD, Yrjö T. Konttinen, MD, PhD, J. Mark Wilkinson, PhD, FRCS(Tr&Orth) and Robert Lane Smith, PhD

Dr. Tuan is Chief, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. Dr. Lee is Associate Professor and Vice Chair for Research, Department of Orthopaedic Surgery, Columbia University, New York, NY. Dr. Konttinen is Professor of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. Dr. Wilkinson is Clinical Senior Lecturer in Orthopaedics, Academic Unit of Bone Metabolism, Northern General Hospital, University of Sheffield, South Yorkshire, UK. Dr. Smith is Professor (Research), Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford, CA.

*The Implant Wear Symposium 2007 Biologic Work Group included Thomas W. Bauer, MD, PhD, Joan Bechtold, PhD, Mathias Bostrom, MD, Patricia A. Campbell, PhD, Victor Goldberg, MD, Stuart B. Goodman, MD, PhD, Ed M. Greenfield, PhD, Joshua J. Jacobs, MD, Yrjö Konttinen, MD, PhD, Regis O’Keefe, MD, PhD, Francis Young-In Lee, MD, Edward M. Schwarz, PhD, Arun S. Shanbhag, PhD, MBA, Robert Lane Smith, PhD, Rocky S. Tuan, PhD, and J. Mark Wilkinson, PhD, FRCS(Tr&Orth).

Dr. Smith or a member of his immediate family has received research or institutional support from Zimmer. None of the following authors or a member of their immediate families has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Tuan, Dr. Lee, Dr. Konttinen, and Dr. Wilkinson.

New clinical and basic science data on the cellular and molecular mechanisms by which wear particles stimulate the host inflammatory response have provided deeper insight into the pathophysiology of periprosthetic bone loss. Interactions among wear particles, macrophages, osteoblasts, bone marrow–derived mesenchymal stem cells, fibroblasts, endothelial cells, and T cells contribute to the production of pro-inflammatory and pro-osteoclastogenic cytokines such as TNF-{alpha}, RANKL, M-SCF, PGE2, IL-1, IL-6, and IL-8. These cytokines not only promote osteoclastogenesis but interfere with osteogenesis led by osteoprogenitor cells. Recent studies indicate that genetic variations in TNF-{alpha}, IL-1, and FRZB can result in subtle changes in gene function, giving rise to altered susceptibility or severity for periprosthetic inflammation and bone loss. Continuing research on the biologic effects and mechanisms of action of wear particles will provide a rational basis for the development of novel and effective ways of diagnosis, prevention, and treatment of periprosthetic inflammatory bone loss. 






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