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J Am Acad Orthop Surg, Vol 16, No suppl_1, July 2008, S56-S62.
© 2008 the American Academy of Orthopaedic Surgeons
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What other biologic and mechanical factors might contribute to osteolysis?

Ed M. Greenfield, PhD and Joan Bechtold, PhD

Dr. Greenfield is Professor, Department of Orthopaedics, Case Western Reserve University, Cleveland, OH. Dr. Bechtold is Director of Research, Midwest Orthopaedic Research Foundation, and Associate Professor, Departments of Mechanical Engineering and Orthopaedic Surgery, University of Minnesota, Minneapolis, MN.

*The Implant Wear Symposium 2007 Biologic Work Group included Thomas W. Bauer, MD, PhD, Joan Bechtold, PhD, Mathias Bostrom, MD, Patricia A. Campbell, PhD, Victor Goldberg, MD, Stuart B. Goodman, MD, PhD, Ed M. Greenfield, PhD, Joshua J. Jacobs, MD, Yrjö Konttinen, MD, PhD, Regis O'Keefe, MD, PhD, Francis Young-In Lee, MD, Edward M. Schwarz, PhD, Arun S. Shanbhag, PhD, MBA, Robert Lane Smith, PhD, Rocky S. Tuan, PhD, and J. Mark Wilkinson, PhD, FRCS(Tr&Orth).

Dr. Bechtold or a member of her immediate family has received nonincome support (such as equipment or services), commercially derived honoraria, or other non-research–related funding (such as paid travel) from Material Transfer Agreement from Biomet, Inc. Neither Dr. Greenfield nor a member of his immediate family has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article.

An overwhelming consensus exists that wear particles are the primary driving force in aseptic loosening of orthopaedic implants. Nonetheless, considerable evidence has emerged demonstrating that various other factors can modulate the biologic activity of orthopaedic wear particles. Two of the most studied modulating factors are bacterial endotoxins and implant motion. 






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