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J Am Acad Orthop Surg, Vol 17, No 10, October 2009, 602-608.
© 2009 the American Academy of Orthopaedic Surgeons
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Platelet-rich Plasma: Current Concepts and Application in Sports Medicine

Michael P. Hall, MD, Phillip A. Band, PhD, Robert J. Meislin, MD, Laith M. Jazrawi, MD and Dennis A. Cardone, DO

Orthopaedic Advances articles provide current information on recent developments in orthopaedic surgery, technology, pharmacotherapeutics, and diagnostic modalities.

Dr. Hall is Resident, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY. Dr. Band is Research Assistant Professor, Department of Pharmacology, NYU School of Medicine, NYU Hospital for Joint Diseases. Dr. Meislin is Assistant Professor, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases. Dr. Jazrwai is Assistant Professor, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases. Dr. Cardone is Associate Professor, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases.

Reprint requests: Dr. Hall, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003.

Dr. Band or a member of his immediate family serves as a consultant to or is an employee of Smith & Nephew. Dr. Meislin or a member of his immediate family serves as a paid consultant to or is an employee of Mitek and has received research or institutional support from Mitek and Smith & Nephew. Dr. Jazrawi or a member of his immediate family is a member of a speakers’ bureau or has made paid presentations on behalf of, has served as a paid consultant to or is an employee of, and has received research or institutional support from Mitek. Dr. Cardone or a member of his immediate family is a member of a speakers’ bureau or has made paid presentations on behalf of Ferring Pharmaceuticals. Neither Dr. Hall nor a member of his immediate family has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article.

Platelet-rich plasma is defined as autologous blood with a concentration of platelets above baseline values. Platelet-rich plasma has been used in maxillofacial and plastic surgery since the 1990s; its use in sports medicine is growing given its potential to enhance muscle and tendon healing. In vitro studies suggest that growth factors released by platelets recruit reparative cells and may augment soft-tissue repair. Although minimal clinical evidence is currently available, the use of platelet-rich plasma has increased, given its safety as well as the availability of new devices for outpatient preparation and delivery. Its use in surgery to augment rotator cuff and Achilles tendon repair has also been reported. As the marketing of platelet-rich plasma increases, orthopaedic surgeons must be informed regarding the available preparation devices and their differences. Many controlled clinical trials are under way, but clinical use should be approached cautiously until high-level clinical evidence supporting platelet-rich plasma efficacy is available.






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Copyright © 2009 by the American Academy of Orthopaedic Surgeons.