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J Am Acad Orthop Surg, Vol 17, No 11, November 2009, 708-717.
© 2009 the American Academy of Orthopaedic Surgeons

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Chordoma of the Sacrum and Vertebral Bodies

Daniel M. Sciubba, MD, Jennifer J. Cheng, MD, Rory J. Petteys, BS, Kristy L. Weber, MD, Deborah A. Frassica, MD and Ziya L. Gokaslan, MD

Dr. Sciubba is Assistant Professor of Neurosurgery, Oncology, and Orthopaedic Surgery, Department of Neurological Surgery, Johns Hopkins University, Baltimore, MD. Dr. Cheng is Resident Physician, Department of Neurological Surgery, Johns Hopkins University. Mr. Petteys is Resident Physician, Department of Neurological Surgery, Georgetown University, Washington, DC. Dr. Weber is Professor of Orthopaedic Surgery, Department of Orthopaedic Surgery, Johns Hopkins University. Dr. Frassica is Associate Professor of Radiation Oncology and Oncology, Department of Radiation Oncology, Johns Hopkins University. Dr. Gokaslan is Professor of Neurosurgery, Oncology, and Orthopaedic Surgery, Department of Neurological Surgery, Johns Hopkins University.

Dr. Sciubba or a member of his immediate family has received research or institutional support from AO, DePuy, and Medtronic Sofamor Danek. Dr. Weber or a member of her immediate family serves as a board member, owner, or committee member of the American Orthopaedic Association, Orthopaedic Research and Education Foundation, Orthopaedic Research Society, Musculoskeletal Tumor Society, and Ruth Jackson Orthopaedic Society. Dr. Gokaslan or a member of his immediate family has received research or institutional support from AO North America and Medtronic, has stock or stock options held in US Spine and Spinal Kinetics, and has received nonincome support (such as equipment or services), commercially derived honoraria, or other non–research-related funding (such as paid travel) from AO North America. None of the following authors or a member of their immediate families has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Cheng, Mr. Petteys, and Dr. Frassica.

Reprint requests: Dr. Sciubba, Department of Neurological Surgery, Johns Hopkins University, 600 North Wolfe Street, Meyer 8-161, Baltimore, MD 21237.

Chordomas are relatively rare tumors of bone. These primary malignant lesions occur throughout the spinal column and often show advanced growth at the time of diagnosis. Because such tumors are minimally responsive to radiation and chemotherapy, surgical resection is the mainstay of treatment. Patient survival and local control are associated with the ability to achieve wide surgical margins during excision. However, surgical morbidity may be substantial given the propensity for chordomas to abut or surround neural, vascular, and visceral structures. Thus, early recognition is essential, and treatment by a multidisciplinary team is ideal.







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Copyright © 2009 by the American Academy of Orthopaedic Surgeons.