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J Am Acad Orthop Surg, Vol 17, No 6, June 2009, 356-368.
© 2009 the American Academy of Orthopaedic Surgeons
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Static and Mobile Antibiotic-impregnated Cement Spacers for the Management of Prosthetic Joint Infection

Cale Jacobs, PhD, Christian P. Christensen, MD and Michael E. Berend, MD

Dr. Jacobs is Director of Development, End Range of Motion Improvement, Inc, Atlanta, GA. Dr. Christensen is Orthopaedic Surgeon, Lexington Clinic, Lexington, KY. Dr. Berend is Orthopaedic Surgeon, Center for Hip and Knee Surgery, Joint Replacement Surgeons of Indiana Research Foundation, St. Francis Hospital, Mooresville, IN.

Dr. Jacobs or a member of his immediate family has received research or institutional support from Biomet and is an employee of End Range of Motion Improvement, Inc. Dr. Christensen or a member of his immediate family has received research or institutional support from Biomet and Smith & Nephew, has received miscellaneous nonincome support from Biomet, and is a consultant to or an employee of Biomet and Stryker. Dr. Berend or a member of his immediate family has received research or institutional support form Biomet, MCS, and St. Francis Hospital; is a member of a speakers’ bureau or has made paid presentations on behalf of Biomet; has received royalties from Biomet; and is a consultant to or an employee of Biomet.

Reprint requests: Dr. Jacobs, ERMI, Inc, 441 Armour Place, Atlanta, GA 30324.

Two-stage treatment is currently the most common approach for management of an infected joint prosthesis in the United States. Static antibiotic-impregnated polymethylmethacrylate cement spacers have traditionally been used; increasingly, however, mobile or articulating spacers are being utilized. Advocates of mobile spacers have cited potential advantages, including more effective maintenance of the joint space, allowing for limited weight bearing and facilitating joint motion; possible reduction in bone loss; and local delivery of antibiotics. Because a variety of materials and construction methods is used to make knee and hip spacers, comparisons are difficult. Randomized, prospective studies are needed to determine the best spacers for total knee and total hip arthroplasties.






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Copyright © 2009 by the American Academy of Orthopaedic Surgeons.