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J Am Acad Orthop Surg, Vol 9, No 1, January/February 2001, 37-52.
© 2001 the American Academy of Orthopaedic Surgeons

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Cartilage Substitutes: Overview of Basic Science and Treatment Options

Douglas W. Jackson, MD, Mark J. Scheer, MD and Timothy M. Simon, PhD

Dr. Jackson is Medical Director, Southern California Center for Sports Medicine, Memorial Orthopaedic Surgical Group, Long Beach, Calif. Dr. Scheer is Sports Medicine Fellow, Southern California Center for Sports Medicine, Memorial Orthopaedic Surgical Group. Dr. Simon is Director of Research, Southern California Center for Sports Medicine, Memorial Orthopaedic Surgical Group.

Reprint requests: Dr. Jackson, 2760 Atlantic Avenue, Long Beach, CA 90806.

Articular cartilage defects that are symptomatic and refractory to nonoperative treatment represent a clinical management challenge. Although there have been important advances in stimulating intrinsic repair mechanisms, cartilage regeneration, and other substitution techniques, to date none has unlocked the understanding necessary to duplicate normal articular cartilage. The objectives of treatment of cartilage lesions are to obtain pain relief, reduce effusions and inflammation, restore function, reduce disability, and postpone or alleviate the need for prosthetic replacement. As the field of articular cartilage repair continues to evolve rapidly, the most appropriate treatment option for an individual patient should be based on the pathologic characteristics of the lesion and the patient’s symptoms and expectations. The orthopaedic surgeon needs to be familiar with both the existing and the newly emerging cartilage treatment techniques in order to best educate patients and meet their expectations for long-term benefits.







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Copyright © 2001 by the American Academy of Orthopaedic Surgeons.